When to use Otoflush® is a revolutionary product designed for use as an in-clinic ear flush as well as a pre-treatment flush for cases of Otitis externa. Otoflush® potentiates antibiotic therapy by allowing greater penetration of antimicrobials and aids in the treatment of these infections, even those demonstrating resistance: Malassezia Staphylococcus E.coli Pseudomona Proteus Otoflush® can also be used as part of a maintenance regime. How to use Instil Otoflush® into ear, massage and allow dog to shake out the excess, wipe clean. Repeat step 1 until solution expelled returns clear. Apply chosen antimicrobial ear drop, ensuring adequate volume reaches target area. Repeat procedure twice daily for length of treatment. For routine cleaning, Otoflush® should be used once weekly as a part of a maintenance regime.